MicroRNA as a diagnostic and therapeutic tool in mononuclear phagocyte mediated retinal inflammation and degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in the industrialised world. Current estimates predict the prevalence of AMD to reach 280 million by 2040, and with no treatments currently available for the more prevalent atrophic form, this number is expected to rise. Underlying disease pathology is increased oxidative stress and non-resolving inflammation attributed to the sustained activation of microglia and macrophages (mononuclear phagocytes (MP)), ultimately...[Show more]
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