Structure determination of protein-ligand complexes by transferred paramagnetic shifts
-
Altmetric Citations
John, Michael; Pintacuda, Guido; Park, Ah Young; Dixon, Nicholas; Otting, Gottfried
Description
Rational drug design depends on the knowledge of the three-dimensional (3D) structure of complexes between proteins and lead compounds of low molecular weight. A novel nuclear magnetic resonance (NMR) spectroscopy strategy based on the paramagnetic effects from lanthanide ions allows the rapid determination of the 3D structure of a small ligand molecule bound to its protein target in solution and, simultaneously, its location and orientation with respect to the protein. The method relies on the...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/21480 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/ja063584z |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_John_Structure_determination_of_2006.pdf | 315.99 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator