Mechanisms of H2A.Z and its Chromatin Remodelling Complexes during the Cell Cycle
The DNA in a cell is packaged into a structure called chromatin. Chromatin structure and function is regulated by epigenetic marks such as the histone H2A.Z. H2A.Z deposition in the genome is regulated by the chromatin remodelling complexes SRCAP and p400. Most research focusses on their roles in transcription, however, the essential roles of H2A.Z go beyond that, as it has roles in the maintenance and inheritance of distinct chromatin states. H2A.Z localises to centromeres, where in mouse TS...[Show more]
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