FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress
The ability to persist in the absence of growth triggered by low oxygen levels is a critical process for the survival of mycobacterial species in many environmental niches. MSMEG_5243 (fsq), a gene of unknown function in Mycobacterium smegmatis, is up-regulated in response to hypoxia and regulated by DosRDosS/DosT, an oxygen- and redox-sensing two-component system that is highly conserved in mycobacteria. In this communication, we demonstrate that MSMEG_5243 is a flavin-sequestering protein and...[Show more]
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|Source:||Journal of Biological Chemistry|
|01_Harold_FAD-sequestering_proteins_2019.pdf||2.56 MB||Adobe PDF||Request a copy|
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