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FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

Harold, Liam K.; Antoney, James; Ahmed, Fathimath; Hards, Kiel; Carr, Paul D.; Rapson, Trevor D.; Greening, Chris; Jackson, Colin; Cook, Greg


The ability to persist in the absence of growth triggered by low oxygen levels is a critical process for the survival of mycobacterial species in many environmental niches. MSMEG_5243 (fsq), a gene of unknown function in Mycobacterium smegmatis, is up-regulated in response to hypoxia and regulated by DosRDosS/DosT, an oxygen- and redox-sensing two-component system that is highly conserved in mycobacteria. In this communication, we demonstrate that MSMEG_5243 is a flavin-sequestering protein and...[Show more]

CollectionsANU Research Publications
Date published: 2018-12-19
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.RA118.006237
Access Rights: Open Access


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