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Structure and function of the endothelial surface layer: unraveling the nanoarchitecture of biological surfaces

Reines, Brandon; Ninham, Barry


Among the unsolved mysteries of modern biology is the nature of a lining of blood vessels called the 'endothelial surface layer' or ESL. In venous micro-vessels, it is half a micron in thickness. The ESL is 10 times thicker than the endothelial glycocalyx (eGC) at its base, has been presumed to be comprised mainly of water, yet is rigid enough to exclude red blood cells. How is this possible? Developments in physical chemistry suggest that the venous ESL is actually comprised of nanobubbles of...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Quarterly Reviews of Biophysics: a review journal of biological function, structure and mechanism
DOI: 10.1017/S0033583519000118
Access Rights: Open Access


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