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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Hughes, Mark M.; Hooftman, Alexander; Angiari, Stefano; TUMMALA, PADMAJA; Zaslona, Zbigniew; Runtsch, Marah C.; McGettrick, Anne F.; Sutton, Caroline E.; Diskin, Ciana; Rooke, Melissa; Takahashi, Shuhei; sundararaj, Srinivasan; Casarotto, Marco; Dahlstrom, Jane; Palsson-McDermott, Eva; Board, Philip


The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/−...[Show more]

CollectionsANU Research Publications
Date published: 2019-10-01
Type: Journal article
Source: Cell Reports
DOI: 10.1016/j.celrep.2019.08.072
Access Rights: Open Access


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