Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
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Hughes, Mark M.; Hooftman, Alexander; Angiari, Stefano; TUMMALA, PADMAJA; Zaslona, Zbigniew; Runtsch, Marah C.; McGettrick, Anne F.; Sutton, Caroline E.; Diskin, Ciana; Rooke, Melissa; Takahashi, Shuhei; sundararaj, Srinivasan; Casarotto, Marco; Dahlstrom, Jane; Palsson-McDermott, Eva; Board, Philip
Description
The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/−...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019-10-01 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/203957 |
Source: | Cell Reports |
DOI: | 10.1016/j.celrep.2019.08.072 |
Access Rights: | Open Access |
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01_Hughes_Glutathione_Transferase_2019.pdf | 3.4 MB | Adobe PDF |
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