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Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins

Grosas, Aidan

Description

Cataract is the world's leading cause of blindness. The destabilization, partial unfolding, and aggregation of lens crystallin proteins cause the loss of lens transparency (opacification) and cataract formation. Numerous congenital mutations and age-related changes to the long-lived alpha-, beta- and gamma-crystallins are associated with cataract and their study has provided insight into the molecular basis of this disease. In this thesis, alpha- and gamma-crystallin isoforms have been...[Show more]

CollectionsOpen Access Theses
Date published: 2020
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/202437
DOI: 10.25911/5e81bcefe7cd3

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