Homologous recombination DNA repair defects in PALB2-associated breast cancers
-
Altmetric Citations
Li, Anqi; Geyer, Felipe C.; Blecua, Pedro; Lee, Ju Young; Selenica, Pier; Brown, David N.; Pareja, Fresia; Lee, Simon S. K.; Kumar, Rahul; Rivera, Barbara; Blackburn, Anneke
Description
Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display biallelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2019-08-08 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/202351 |
Source: | Breast Cancer |
DOI: | 10.1038/s41523-019-0115-9 |
Access Rights: | Open Access |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Li_Homologous_recombination_DNA_2019.pdf | 2.1 MB | Adobe PDF |
This item is licensed under a Creative Commons License
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator