Skip navigation
Skip navigation

Homologous recombination DNA repair defects in PALB2-associated breast cancers

Li, Anqi; Geyer, Felipe C.; Blecua, Pedro; Lee, Ju Young; Selenica, Pier; Brown, David N.; Pareja, Fresia; Lee, Simon S. K.; Kumar, Rahul; Rivera, Barbara; Blackburn, Anneke

Description

Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display biallelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer...[Show more]

CollectionsANU Research Publications
Date published: 2019-08-08
Type: Journal article
URI: http://hdl.handle.net/1885/202351
Source: Breast Cancer
DOI: 10.1038/s41523-019-0115-9
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Li_Homologous_recombination_DNA_2019.pdf2.1 MBAdobe PDFThumbnail


This item is licensed under a Creative Commons License Creative Commons

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator