Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain
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Izoré, Thierry; Tailhades, Julien; Hansen, Mathias Henning; Kaczmarski, Joe Alexander; Jackson, Colin; Cryle, Max
Description
The protein Ebony from Drosophila melanogaster plays a central role in the regulation of histamine and dopamine in various tissues through condensation of these amines with β-alanine. Ebony is a rare example of a nonribosomal peptide synthetase (NRPS) from a higher eukaryote and contains a C-terminal sequence that does not correspond to any previously characterized NRPS domain. We have structurally characterized this C-terminal domain and have discovered that it adopts the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/196651 |
Source: | Proceedings of the National Academy of Sciences |
DOI: | 10.1073/pnas.1811194116 |
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01_Izor%C3%A9_Drosophila_melanogaster_2019.pdf | 1.1 MB | Adobe PDF | Request a copy |
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