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Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

Izoré, Thierry; Tailhades, Julien; Hansen, Mathias Henning; Kaczmarski, Joe Alexander; Jackson, Colin; Cryle, Max


The protein Ebony from Drosophila melanogaster plays a central role in the regulation of histamine and dopamine in various tissues through condensation of these amines with β-alanine. Ebony is a rare example of a nonribosomal peptide synthetase (NRPS) from a higher eukaryote and contains a C-terminal sequence that does not correspond to any previously characterized NRPS domain. We have structurally characterized this C-terminal domain and have discovered that it adopts the...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.1811194116


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