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The interactive role of STAC3 in the skeletal excitation-contraction coupling machinery

Aditya, Shouvik

Description

Excitation-contraction (EC) coupling in skeletal muscle is an essential cellular process that requires a physical coupling between the dihydropyridine receptor (DHPR) L-type Ca2+ channel or CaV1.1 in the surface membrane, and the ryanodine receptor (RyR1) Ca2+ release channel in the sarcoplasmic reticulum (SR) membrane. However, the exact nature of the molecular interaction between the dihydropyridine receptor and the ryanodine receptor in skeletal muscle remains unclear. Recently, the adaptor...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/193522
DOI: 10.25911/5df9f26758a9b

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