Sex-Specific Biology of Plasmodium falciparum
Malaria, caused by Plasmodium parasites, is responsible for almost 500,000 deaths annually. Disease transmission requires the parasite to differentiate into male and female gametocytes in human red blood cells prior to sexual reproduction upon ingestion by a mosquito. This thesis addresses fundamental questions about the sex-specific development of Plasmodium gametocytes to guide transmission-blocking antimalarial interventions. Although Plasmodium depends on host nutrients to survive,...[Show more]
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