Skip navigation
Skip navigation

The Persistent Sodium Current Blocker Riluzole Is Antiarrhythmic and Anti-Ischaemic in a Pig Model of Acute Myocardial Infarction

Weiss, Steven M.; Saint, David A.


BACKGROUND The potential of the cardiac persistent sodium current as a target for protection of the myocardium from ischaemia and reperfusion injury is gaining increasing interest. We have investigated the anti-ischaemic and antiarrhythmic effects of riluzole, a selective INaP blocker, in an open chest pig model of infarction. METHODS AND PRINCIPAL FINDINGS The left anterior descending coronary artery (LAD) was ligated in 27 anesthetised pigs (landrace or large white, either sex, 20-35 kg)...[Show more]

CollectionsANU Research Publications
Date published: 2010-11-24
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0014103


File Description SizeFormat Image
01_Weiss_The_Persistent_Sodium_Current_2010.pdfPublished Version2.13 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator