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The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin

Ryan, Daniel; Tremethick, David

Description

One of the most intensively studied chromatin binding factors is HP1α. HP1α is associated with silenced, heterochromatic regions of the genome and binds to H3K9me3. While H3K9me3 is necessary for HP1α recruitment to heterochromatin, it is becoming apparent that it is not sufficient suggesting that additional factors are involved. One candidate proposed as a potential regulator of HP1α recruitment is the linker histone H1.4. Changes to the underlying make-up of chromatin, such as the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/159679
Source: Nucleic Acids Research
DOI: 10.1093/nar/gky632

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