Beta cell stress and heparan sulfate proteoglycans in type 2 diabetes
Heparan sulfate proteoglycan (HSPG) core proteins and highly sulfated heparan sulfate (HS) are expressed at unusually high levels inside islet beta cells. Intracellular HS plays a critical role in the survival of beta cells and acts as a constitutive non-enzymatic quencher of reactive oxygen species (ROS). Heparanase (Hpse)-mediated degradation of intracellular HS in the beta cells of non-obese diabetic (NOD) mice has been shown to contribute to the development of type 1 diabetes (T1D). This...[Show more]
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