Interactions between the dihydropyridine receptor beta1a subunit and the ryanodine receptor from skeletal muscle
Excitation-contraction (EC) coupling describes the process that links the excitatory action potential to muscle fibre contraction. Essential to this process is the release of Ca2+ from the sarcoplasmic reticulum (SR) via the ligand gated ryanodine receptor (RyR) in the SR membrane. In cardiac muscle fibres, RyR2 (cardiac isoform) activation is initiated by Ca2+ entry through the cardiac L-type voltage-gated dihydropyridine receptor (DHPR). In contrast, EC coupling in skeletal muscle fibres...[Show more]
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