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HIV-1 vaccine development : evaluating mechanisms of CD8+ T cell avidity

Wijesundara, Danushka

Description

CD8+ T cells play pivotal roles in anti-viral immunity. In particular, CD8+ T cells that make high avidity interactions with virus-infected cells are extremely efficient in controlling virus infections including human immunodeficiency virus (HIV)-1. Therefore, induction of high avidity anti-viral CD8+ T cells following vaccination is expected to be beneficial for conferring protection against HIV-1. Our laboratory has shown that mucosal HIV-1 recombinant pox viral prime-boost vaccination can...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/155844
DOI: 10.25911/5d514de2bc305

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