HIV-1 vaccine development : evaluating mechanisms of CD8+ T cell avidity
CD8+ T cells play pivotal roles in anti-viral immunity. In particular, CD8+ T cells that make high avidity interactions with virus-infected cells are extremely efficient in controlling virus infections including human immunodeficiency virus (HIV)-1. Therefore, induction of high avidity anti-viral CD8+ T cells following vaccination is expected to be beneficial for conferring protection against HIV-1. Our laboratory has shown that mucosal HIV-1 recombinant pox viral prime-boost vaccination can...[Show more]
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