Investigating the Prevalence of an Unusual Form of Alternative Splicing
This study identified 2567 potential novel protein isoforms, across seven different species, which have been overlooked by previous large-scale studies. These arise due to an unusual outcome of alternative splicing which combines a frame-shift with an alternate start-codon in order to shift the reading frame of the protein's amino-terminus. First encountered by the Fahrer laboratory in the mouse Ncaph2 gene, only four instances of this splicing are reported in the literature, none of which...[Show more]
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