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Investigating the Prevalence of an Unusual Form of Alternative Splicing

Wilson, Laurence Oscar

Description

This study identified 2567 potential novel protein isoforms, across seven different species, which have been overlooked by previous large-scale studies. These arise due to an unusual outcome of alternative splicing which combines a frame-shift with an alternate start-codon in order to shift the reading frame of the protein's amino-terminus. First encountered by the Fahrer laboratory in the mouse Ncaph2 gene, only four instances of this splicing are reported in the literature, none of which...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/155709
DOI: 10.25911/5d5141934b1a0

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