A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5 '-3 ' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe
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Tucker, James Franklin; Ohle, Corina; Schermann, Geza; Bendrin, Katja; Zhang, Wei; Fischer, Tamas; Zhang, Ke
Description
Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes. In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways including RNA interference (RNAi) and a 3’-5’ exoribonuclease complex, the exosome. Here, we report a new RNA-processing pathway that contributes to epigenetic gene silencing and assembly of...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/153189 |
Source: | PLoS Genetics |
DOI: | 10.1371/journal.pgen.1005873 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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01_Tucker_A_Novel_Epigenetic_Silencing_2016.pdf | 7.53 MB | Adobe PDF |
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