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Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

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Ho, Carrie; Wu, Steven; Amos, Joshua D.; Colvin, Lisa; Smith, Shannon D.; Wilks, Andrew B.; DeMarco, C. Todd; Brinkley, Christie; Denny, Thomas N.; Schmitz, Joern E.; Rodrigo, Allen; Permar, Sallie R.

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Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not...[Show more]

dc.contributor.authorHo, Carrie
dc.contributor.authorWu, Steven
dc.contributor.authorAmos, Joshua D.
dc.contributor.authorColvin, Lisa
dc.contributor.authorSmith, Shannon D.
dc.contributor.authorWilks, Andrew B.
dc.contributor.authorDeMarco, C. Todd
dc.contributor.authorBrinkley, Christie
dc.contributor.authorDenny, Thomas N.
dc.contributor.authorSchmitz, Joern E.
dc.contributor.authorRodrigo, Allen
dc.contributor.authorPermar, Sallie R.
dc.date.accessioned2018-11-29T22:52:59Z
dc.date.available2018-11-29T22:52:59Z
dc.identifier.issn0022-538X
dc.identifier.urihttp://hdl.handle.net/1885/152344
dc.description.abstractNatural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
dc.format.mimetypeapplication/pdf
dc.publisherAmerican Society for Microbiology
dc.sourceJournal of Virology
dc.subjectKeywords: article; breast milk; Chlorocebus; gene amplification; genetic variability; nonhuman; phylogeny; priority journal; Simian immunodeficiency virus; virus load; virus replication; virus transmission; Animals; Cercopithecus aethiops; Cluster Analysis; Female;
dc.titleTransient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume87
dc.date.issued2013
local.identifier.absfor010402 - Biostatistics
local.identifier.absfor060411 - Population, Ecological and Evolutionary Genetics
local.identifier.absfor080301 - Bioinformatics Software
local.identifier.ariespublicationU3488905xPUB5618
local.type.statusPublished Version
local.contributor.affiliationHo, Carrie, Duke University Medical Center
local.contributor.affiliationWu, Steven, Duke University
local.contributor.affiliationAmos, Joshua D., Duke University Medical Center
local.contributor.affiliationColvin, Lisa, Duke University Medical Center
local.contributor.affiliationSmith, Shannon D., Duke University Medical Center
local.contributor.affiliationWilks, Andrew B., Beth Israel Deaconess Medical Center
local.contributor.affiliationDeMarco, C. Todd, Duke University Medical Center
local.contributor.affiliationBrinkley, Christie, Duke University Medical Center
local.contributor.affiliationDenny, Thomas N., Duke University Medical Center
local.contributor.affiliationSchmitz, Joern E., Beth Israel Deaconess Medical Center
local.contributor.affiliationRodrigo, Allen, College of Science, ANU
local.contributor.affiliationPermar, Sallie R., Duke University Medical Center
local.bibliographicCitation.issue20
local.bibliographicCitation.startpage11292
local.bibliographicCitation.lastpage11299
local.identifier.doi10.1128/JVI.01643-13
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2018-11-29T07:50:23Z
local.identifier.scopusID2-s2.0-84886887750
local.identifier.thomsonID000325275800033
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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