Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccinehas not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuatedwhole-parasite vaccines are now receiving close scrutiny. Here, we test chemically attenuated Plasmodium yoelii 17Xand demonstrate significant protection following homologous and heterologous blood-stage challenge. Protection...[Show more]
|Collections||ANU Research Publications|
|Source:||Infection and Immunity|
|Access Rights:||Open Access|
|01_Raja_Chemically_attenuated_2016.pdf||3.91 MB||Adobe PDF|
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