Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
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Raja, Amber I; Cai, Yeping; Reiman, Jennifer M; Groves, Penny; Chakravarty, Sumana; McPhun, Virginia; Doolan, Denise L; Cockburn, Ian; Hoffman, Stephen L; Stanisic, Danielle I; Good, Michael F
Description
The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccinehas not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuatedwhole-parasite vaccines are now receiving close scrutiny. Here, we test chemically attenuated Plasmodium yoelii 17Xand demonstrate significant protection following homologous and heterologous blood-stage challenge. Protection...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/152289 |
Source: | Infection and Immunity |
DOI: | 10.1128/IAI.00157-16 |
Access Rights: | Open Access |
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01_Raja_Chemically_attenuated_2016.pdf | 3.91 MB | Adobe PDF |
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