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Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection

Raja, Amber I; Cai, Yeping; Reiman, Jennifer M; Groves, Penny; Chakravarty, Sumana; McPhun, Virginia; Doolan, Denise L; Cockburn, Ian; Hoffman, Stephen L; Stanisic, Danielle I; Good, Michael F

Description

The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccinehas not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuatedwhole-parasite vaccines are now receiving close scrutiny. Here, we test chemically attenuated Plasmodium yoelii 17Xand demonstrate significant protection following homologous and heterologous blood-stage challenge. Protection...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152289
Source: Infection and Immunity
DOI: 10.1128/IAI.00157-16
Access Rights: Open Access

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