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Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2A proteins of Murray Valley encephalitis virus

Addis, Siti Nor Khadijah

Description

Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151244
DOI: 10.25911/5d51531a970be
Access Rights: Open Access

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