The role of chromatin in T cell gene transcription
Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is also growing evidence that genes that respond to environmental or developmental signals may possess distinct chromatin marks. Using two approaches, mining of ChIP-seq data and ChIP-qPCR for individual genes, this thesis sought to define the chromatin signature of inducible genes in T cells. Inducible genes with low basal expression,...[Show more]
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