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Evaluation of viral cytokine vectors for gene therapy

Sutherland, Duncan Bruce


Viral-vectors encoding adjuvant cytokines have applications in vaccine development, gene therapy and immunology research. Virally encoded cytokines have been shown to limit viral-vector replication yet enhance immune responses in animal models. Nevertheless, concerns over the safety of this technology remain, which has prevented licensing for human use. Cytokines are immune modulators that can display context specific properties; therefore the virally encoded cytokines have the potential to...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
DOI: 10.25911/5d5fcbcc09447
Access Rights: Open Access


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