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Elucidation of the mechanism(s) required by CD8{u207A} T lymphocytes for control of different viral infections

Wong, Wai-Yu


CD8{u207A} Cytotoxic T lymphocytes (CTLs) are efficient in controlling virus infection because they are equipped with multiple effector mechanisms capable of either inducing cell death or an antiviral state within infected cells. These effector molecules include perforin (Prf), granzymes (Gzms) and gamma-interferon (IFN-{u03B3}). Through the use of gene knockout animals in various viral models, it is now well established that a deficit in any of these effector functions can result in a loss of...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)


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