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Neuronal cilia and appetite regulation in Alms1 mutant mice

Heydet, Deborah

Description

The foz/foz mouse is a murine model of Alstr{u00F6}m syndrome, a monogenetic disorder characterised in humans by childhood obesity, hearing loss, blindness, hyperinsulinaemia, early-onset type 2 diabetes and liver disease. In 2006, research from the host laboratory reported that foz/foz mice inherit a spontaneous mutation (foz) , an 11 base pair deletion in exon 8 of the Alms1 gene, and develop a similar phenotype to patients suffering from Alstr{u00F6}m syndrome. Thus, foz/foz mice are obese...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/148260
DOI: 10.25911/5d63bffa162f9

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