Sugrue, Elena; Fraser, Nicholas J; Hopkins, Davis H; Carr, Paul D; Khurana, Jeevan L; Oakeshott, John Graham; Scott, Colin; Jackson, Colin J
The amidohydrolase superfamily has remarkable functional diversity, with considerable structural and functional annotation of known sequences. In microbes, the recent evolution of several members of this family to catalyze the breakdown of environmental xenobiotics is not well understood. An evolutionary transition from binuclear to mononuclear metal ion coordination at the active sites of these enzymes could produce large functional changes such as those observed in nature, but there are few...[Show more]
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