Quantitative dissection of T cell negative selection mechanisms in the thymus
While many factors can influence the fate of developing T cells in the thymus, among the most influential are the strength and timing of signals transmitted by the T cell antigen receptor (TCR). Weak TCR binding to peptide/major histocompatibility complex (MHC) ligands induces thymocytes to develop into naïve T cells, a process called positive selection. Mechanisms that prevent naive T cell development are termed “negative selection” and include apoptotic...[Show more]
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