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Characterisation and directed evolution of novel metallo-β-lactamases - spr-1 and aim-1

Hou, Chun-Feng David


Metallo-β-lactamases (MBLs) are zinc ion dependent enzymes that responsible for the emergence and spread of β-lactam resistance. The increasing number of novel members of this family is threatening to global health care. MBLs are divided into three subclasses, i.e. B1, B2 and B3. The recent discovery of an unusual MBL from Serratia proteamaculans (SPR-1) suggests the presence of an additional subgroup, i.e. B4. A database search reveals that...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)


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