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An Investigation Into The Prevention Of Cisplatin-Induced Nephrotoxicity By Dichloroacetate

Galgamuwa Arachchige, Ramindhu


Cisplatin is a highly effective anticancer drug used to treat a range of cancers. However, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. Dichloroacetate (DCA), which has been used to treat lactic acidosis, has emerged over the past decade as a novel anticancer medication. This is primarily due to its ability to reverse the glycolytic phenotype of cancer cells (the Warburg effect). A number of clinical trials assessing...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)


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