Skip navigation
Skip navigation

An Investigation Into The Prevention Of Cisplatin-Induced Nephrotoxicity By Dichloroacetate

Galgamuwa Arachchige, Ramindhu


Cisplatin is a highly effective anticancer drug used to treat a range of cancers. However, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. Dichloroacetate (DCA), which has been used to treat lactic acidosis, has emerged over the past decade as a novel anticancer medication. This is primarily due to its ability to reverse the glycolytic phenotype of cancer cells (the Warburg effect). A number of clinical trials assessing...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)
DOI: 10.25911/5d74e582c8010


File Description SizeFormat Image
Galgamuwa Arachchige Thesis 2017.pdf15.56 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator