B cell and CD8- dendritic cell survival require CD74 proteolysis by the intramembrane endopeptidase SPPL2A
Unknown mechanisms that cause failures in B cell development can lead to humoral immunodeficiencies, autoimmune disorders or B cell malignancies. This thesis demonstrates that the endosomal intramembrane cleaving protease signal-peptide-peptidase-like 2A (SPPL2A) is critical for survival of developing B cells and reveals SPPL2A-deficiency as a previously unknown mechanism of B cell loss. Mice with an ENU-mutagenesis-induced inactivating mutation in Sppl2a...[Show more]
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