Skip navigation
Skip navigation

B cell and CD8- dendritic cell survival require CD74 proteolysis by the intramembrane endopeptidase SPPL2A

Bergmann, Hannes

Description

Unknown mechanisms that cause failures in B cell development can lead to humoral immunodeficiencies, autoimmune disorders or B cell malignancies. This thesis demonstrates that the endosomal intramembrane cleaving protease signal-peptide-peptidase-like 2A (SPPL2A) is critical for survival of developing B cells and reveals SPPL2A-deficiency as a previously unknown mechanism of B cell loss. Mice with an ENU-mutagenesis-induced inactivating mutation in Sppl2a...[Show more]

CollectionsRestricted Theses
Date published: 2016
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/111074
DOI: 10.25911/5d7634cebddd6
Embargoed until: 2021-12-11

Download

File Description SizeFormat Image
Bergmann Thesis 2016.pdf290.19 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator