Consequences of oncogenic CARD11 signalling for B cells
Diffuse large B cell lymphoma is the most common form of Non Hodgkin’s lymphoma, accounting for forty percent of cases. Gain of function CARD11 mutations have been found in approximately thirteen percent of DLBCL patients. CARD11 functions as a scaffold protein and relays signals from the antigen receptor to the JNK and NFkB signaling pathways, which contribute to the survival, proliferation and differentiation of lymphocytes. The consequences of acquiring...[Show more]
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