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Uncovering new functions for histone variants: a role for H2A.Z in silencing retrotransposons

Shen, Qian

Description

Eukaryotic genomes must be, on the one hand, highly compacted by wrapping their DNA around histones to form nucleosomes while on the other, still remain accessible to the transcriptional machinery in a developmental and cell-type specific manner. Various epigenetic-based mechanisms exist that can regulate DNA accessibility ensuring the proper regulation of gene transcription. One epigenetic modification in particular that impacts all aspects of genome function...[Show more]

CollectionsOpen Access Theses
Date published: 2016-03
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/104595

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