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Relaxin regulates vascular wall remodeling and passive mechanical properties in mice

Debrah, Dan O.; Debrah, Julianna E.; Haney, Jamie L.; McGuane, Jonathan T.; Sacks, Michael S.; Conrad, Kirk P.; Shroff, Sanjeev G.

Description

Administration of recombinant human relaxin (rhRLX) to conscious rats increases global arterial compliance, and small renal arteries (SRA) isolated from these rats demonstrate increased passive compliance. Here we characterize relaxin-induced vascular remodeling and examine its functional relevance. SRA and external iliac arteries (EIA) were examined in rhRLX-treated (1.0 μg/h for 5 days) and relaxin knockout mice. Arterial geometric remodeling and compositional remodeling were quantified using...[Show more]

CollectionsANU Research Publications
Date published: 2011-07
Type: Journal article
URI: http://hdl.handle.net/1885/100224
Source: Journal of applied physiology (Bethesda, Md. : 1985)
DOI: 10.1152/japplphysiol.00845.2010

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