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Ganglion Blockade does not prevent cortisol-induced hypertension in man

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Williamson, Paula M; Tam, Sim Hom; Kelly, John J; Whitworth, Judith

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1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered...[Show more]

dc.contributor.authorWilliamson, Paula M
dc.contributor.authorTam, Sim Hom
dc.contributor.authorKelly, John J
dc.contributor.authorWhitworth, Judith
dc.date.accessioned2015-12-13T22:58:00Z
dc.identifier.issn0305-1870
dc.identifier.urihttp://hdl.handle.net/1885/83230
dc.description.abstract1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.
dc.publisherBlackwell Science Asia
dc.sourceClinical and Experimental Pharmacology and Physiology
dc.subjectKeywords: hydrocortisone; trimetaphan; article; autonomic nervous system function; blood pressure regulation; controlled study; ganglion block; human; human experiment; hypertension; male; pharmacological blocking; sympathetic tone; Autonomic Nervous System; Blood Blood pressure; Cortisol; Ganglion blockade; Humans; Steroids
dc.titleGanglion Blockade does not prevent cortisol-induced hypertension in man
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume32
dc.date.issued2005
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)
local.identifier.ariespublicationMigratedxPub11453
local.type.statusPublished Version
local.contributor.affiliationWilliamson, Paula M, University of New South Wales
local.contributor.affiliationTam, Sim Hom, University of New South Wales
local.contributor.affiliationKelly, John J, University of New South Wales
local.contributor.affiliationWhitworth, Judith, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage294
local.bibliographicCitation.lastpage296
local.identifier.doi10.1111/j.1440-1681.2005.04220.x
dc.date.updated2015-12-12T07:20:17Z
local.identifier.scopusID2-s2.0-17844377555
CollectionsANU Research Publications

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