Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen
The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of...[Show more]
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|Source:||Journal of Stem Cells|
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