Interaction of the antitumor antibiotic streptonigrin with metal ions and DNA
Streptonigrin is a functionalized 7-aminoquinoline-5,8-dione that is highly active against a range of human cancers. While streptonigrin was in clinical use until 1977, the mechanism of antitumor action of the drug was only investigated in detail after clinical trials were discontinued. In common with other aminoquinone antitumor antibiotics, extensive studies suggest that streptonigrin exerts its antitumor activity by causing DNA strand scission. Metal ions were identified as serving a key...[Show more]
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|Source:||Current Medicinal Chemistry|
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