Garcia De Vinuesa, Maria Carola; Linterman, Michelle; Goodnow, Christopher; Randall, Katrina
Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B-cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non-self-reactive B cells to become long-lived memory B cells and plasma cells. While the precise mechanism of selection is still poorly understood, the last decade has advanced our understanding of the role of T cells and follicular dendritic cells (FDCs) in GC B-cell...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.