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T cells and follicular dendritic cells in germinal center B-cell formation and selection

Garcia De Vinuesa, Maria Carola; Linterman, Michelle; Goodnow, Christopher; Randall, Katrina


Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B-cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non-self-reactive B cells to become long-lived memory B cells and plasma cells. While the precise mechanism of selection is still poorly understood, the last decade has advanced our understanding of the role of T cells and follicular dendritic cells (FDCs) in GC B-cell...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Immunological Reviews
DOI: 10.1111/j.1600-065X.2010.00937.x


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