T cells and follicular dendritic cells in germinal center B-cell formation and selection
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Garcia De Vinuesa, Maria Carola; Linterman, Michelle; Goodnow, Christopher; Randall, Katrina
Description
Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B-cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non-self-reactive B cells to become long-lived memory B cells and plasma cells. While the precise mechanism of selection is still poorly understood, the last decade has advanced our understanding of the role of T cells and follicular dendritic cells (FDCs) in GC B-cell...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/66187 |
Source: | Immunological Reviews |
DOI: | 10.1111/j.1600-065X.2010.00937.x |
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01_Garcia De Vinuesa_T_cells_and_follicular_2010.pdf | 530.47 kB | Adobe PDF | Request a copy |
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