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Evidence for Gliotoxin-Glutathione Conjugate Adducts

Bernardo, Paul; Chai, Christina; Deeble, Geoffrey; Liu, Xi; Waring, Paul


The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/S0960-894X(00)00696-X


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