Evidence for Gliotoxin-Glutathione Conjugate Adducts
The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.
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|Source:||Bioorganic and Medicinal Chemistry Letters|
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