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Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens

Moutaftsi, Magdalini; Tscharke, David; Vaughan, Kerrie; Koelle, David; Stern, Lawrence; Calvo-Calle, Mauricio; Ennis, Francis; Terajima, Masanori; Sutter, Gerd; Crotty, Shane; Drexler, Ingo; Franchini, Genoveffa; Yewdell, Jonathan W; Head, Steven R.; Blum, Janice; Peters, Bjoern; Sette, Alessandro

Description

Vaccinia virus (VACV) was used as the vaccine strain to eradicate smallpox. VACV is still administered to healthcare workers or researchers who are at risk of contracting the virus, and to military personnel. Thus, VACV represents a weapon against outbreaks, both natural (e.g., monkeypox) or man-made (bioterror). This virus is also used as a vector for experimental vaccine development (cancer/infectious disease). As a prototypic poxvirus, VACV is a model system for studying host-pathogen...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/32809
Source: Future Microbiology
DOI: 10.2217/fmb.09.110

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