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Modulation of roquin function in myeloid cells reduces mycobacterium tuberculosis-induced inflammation

Nagalingam, Gayathri; Garcia De Vinuesa, Maria Carola; Britton, Warwick; Saunders, Bernadette

Description

Damaging inflammation is a hallmark of Mycobacterium tuberculosis infection, and understanding how this is regulated is important for the development of new therapies to limit excessive inflammation. The E3 ubiquitin ligase, Roquin, is involved in immune regulation; however, its role in immunity to M. tuberculosis is unknown. To address this, we infected mice with a point mutation in Roquin1/Rc3h1 (sanroque). Aerosol-infected sanroque mice showed enhanced control of M. tuberculosis infection...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218234
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1602069

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