A Tale of Two Alpha's: Design of Selective Agonists and Modulators Targeting the a4-a4 Binding Site of (a4)3(b2)2 Nicotinic Acetylcholine Receptors
The a4b2 nicotinic acetylcholine receptor (nAChR), belonging to the family of 'Cys-loop' pentameric ligand-gated ion channels, is one of the most abundant subtypes found in the brain. Several researches have concluded its important role in modulating memory, sleep and attention. Thereby, making it an attractive druggable target due to its implication in several neurological, and psychiatric disorders such as Alzheimer's disease, Attention Deficit Hyperactivity Disorder (ADHD) and nicotine...[Show more]
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