AMPK Activation prevents and reverses drug-induced mitochondrial and hepatocyte injury by promoting mitochondrial fusion and function
Mitochondrial damage is the major factor underlying drug-induced liver disease but whether conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage is unclear. A key molecule regulating mitochondria quality control is AMP activated kinase (AMPK). When activated, AMPK causes mitochondria to elongate/fuse and proliferate, with mitochondria now producing more ATP and less reactive oxygen species. Autophagy is also triggered, a process capable of removing...[Show more]
|Collections||ANU Research Publications|
|Source:||PLOS ONE (Public Library of Science)|
|Access Rights:||Open Access|
|01_Kang_AMPK_Activation_prevents_and_2016.pdf||6.25 MB||Adobe PDF|
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