Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccine has not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuated whole-parasite vaccines are now receiving close scrutiny. Here, we test chemically attenuated Plasmodium yoelii 17X and demonstrate significant protection following homologous and heterologous blood-stage challenge. Protection...[Show more]
|Collections||ANU Research Publications|
|Source:||Infection and immunity|
|01 Raja A I et al Chemically attenuated blood stage 2016.pdf||1.88 MB||Adobe PDF|
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