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Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection

Raja, Amber I; Cai, Yeping; Reiman, Jennifer M; Groves, Penny; Chakravarty, Sumana; McPhun, Virginia; Doolan, Denise L; Cockburn, Ian; Hoffman, Stephen L; Stanisic, Danielle I; Good, Michael F


The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccine has not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuated whole-parasite vaccines are now receiving close scrutiny. Here, we test chemically attenuated Plasmodium yoelii 17X and demonstrate significant protection following homologous and heterologous blood-stage challenge. Protection...[Show more]

CollectionsANU Research Publications
Date published: 2016-08
Type: Journal article
Source: Infection and immunity
DOI: 10.1128/IAI.00157-16


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