Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition

Issa, FatiahKassiou, MichaelChan, Hak-KimMcLeod, Malcolm2015-12-100004-9425http://hdl.handle.net/1885/52882Ipratropium bromide [(1R,3r,5S,8r,2′RS)-3-(3′-hydroxy-2′- phenylpropionyloxy)-8-isopropyl-8-methyl-8-aza-bicyclo[3.2.1]octan-8-ium bromide] and tiotropium bromide [(1R,2R,4S,5S,7s)-7-[2′-hydroxy-2′, 2′-di(thiophen2″-yl)acetoxy]-9,9-dimethyl-Keywords: Amines; Aromatic compounds; Bromine compounds; Positron emission tomography; Pulmonary diseases; Synthesis (chemical); Drug deposition; Ipratropium; Radiochemical purity; Radioligands; Drug productsSynthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition200610.1071/CH053032015-12-09