Transcriptional Repressor Blimp-1 Promotes CD8 + T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

Rutishauser, RachelMartins, GislaineKalachikov, SergeyChandele, AnmolParish, IanMeffre, EricJacob, JoshyCalame, KathrynKaech, Susan2015-12-081074-7613http://hdl.handle.net/1885/37486During acute infections, a small population of effector CD8+ T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional repressor Blimp-1 enhanced the formation of terminally differentiatedKeywords: B lymphocyte induced maturation protein 1; interleukin 2; L selectin; repressor protein; animal cell; animal experiment; animal tissue; article; CD8+ T lymphocyte; cell survival; controlled study; lymphocyte differentiation; lymphocyte proliferation; Lymp CELLIMUNO; MOLIMMUNOTranscriptional Repressor Blimp-1 Promotes CD8 + T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties200910.1016/j.immuni.2009.05.0142016-02-24