Harrison, JodieRamshaw, Ian2015-12-131074-7613http://hdl.handle.net/1885/78091Patients with atopic dermatitis (AD) have an increased risk of infection with several viruses compared to patients with other inflammatory skin disorders such as psoriasis. In this issue of Immunity, Howell et al. (2006) find that the cytokine milieu in the skin of AD patients profoundly affects the innate response to vaccinia virus (VV) by blocking production of the antimicrobial peptide LL-37.Keywords: alpha1 interferon; antimicrobial peptide ll 37; beta1 interferon; cathelicidin; cathelin; cell protein; cytokine; defensin; gamma interferon; immunoglobulin enhancer binding protein; interleukin 13; interleukin 4; smallpox vaccine; STAT6 protein; unclassi200610.1016/j.immuni.2006.03.0032015-12-11