McDevitt, Christopher A.Shintre, Chitra A.Grossmann, J GunterPollock, Naomi L.Prince, StephenFord, Robert C.Callaghan, Richard2015-12-130014-5793http://hdl.handle.net/1885/71144P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.Keywords: glycoprotein P; article; controlled study; gel permeation chromatography; nonhuman; polyacrylamide gel electrophoresis; priority journal; protein folding; protein purification; protein structure; X ray crystallography; Bacterial Proteins; Cryoelectron Mic ABCB1; Electron crystallography; Membrane protein; Multidrug resistance; Protein structure; SAXS200810.1016/j.febslet.2008.07.0222015-12-11