Mutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil

Hayward, RhysSaliba, KevinKirk, Kiaran2015-12-130066-4804http://hdl.handle.net/1885/83222As well as having the ability to reverse chloroquine resistance in the human malaria parasite Plasmodium falciparum, verapamil has itself an innate antiplasmodial activity. We show here that mutations in Pgh1, the product of the malaria parasite's pfmdr1Keywords: chloroquine; halofantrine; mefloquine; verapamil; antibiotic resistance; article; DNA polymorphism; drug activity; drug effect; gene; gene mutation; genetic susceptibility; nonhuman; pfmdr1 gene; Plasmodium falciparum; priority journal; sensitivity analysMutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil200510.1128/AAC.49.2.840-842.20052015-12-12