Breen, SusanWilliams, SimonSolomon, PeterOUTRAM, Megan AKobe, Bostjan2021-06-151360-1385http://hdl.handle.net/1885/237337The members of the pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack, and PR-1 gene expression has long been used as a marker for salicylic acid-mediated disease resistance. However, despite considerable interest over several decades, their requirement and role in plant defence remains poorly understood. Recent reports have emerged demonstrating that PR-1 proteins possess sterol-binding activity, harbour an embedded defence signalling peptide, and are targeted by plant pathogens during host infection. These studies have reenergised the field and provided long-awaited insights into a possible PR-1 function. Here we review the current status of PR-1 proteins and discuss how these recent advances shed light on putative roles for these enigmatic proteins.application/pdfen-AU© 2017 Elsevier Ltd201710.1016/j.tplants.2017.06.0132020-11-23