Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis

Mullbacher, ArnoLobigs, MarioTha Hla, RonTran, Thao (Thomas)Stehle, ThomasSimon, Markus M2015-12-130022-1767http://hdl.handle.net/1885/72973Effector cytolytic T (Tc) lymphocytes, deficient in the exocytosis-mediated pathway of target cell lysis, induce Fas on target cells and, in turn, delayed cell death and apoptosis via the Fas ligand-Fas interaction. The induction of Fas can be blocked byKeywords: antibody; Fas antigen; FAS ligand; major histocompatibility antigen; recombinant gamma interferon; T lymphocyte receptor; animal cell; apoptosis; article; bystander effect; cell death; cytolysis; cytotoxic T lymphocyte; effector cell; exocytosis; knockoutAntigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis20022015-12-11